Nature Immunology is a multidisciplinary journal that publishes papers of the highest quality and significance in all areas of immunology. Priority is given to work that provides translational and/or fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity; tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also publishes comments, News and Views, research highlights, matters arising from readers and reviews of the literature, thus serving as the major conduit of top-quality information for the immunology community.