The most highly rated peer-reviewed, primary research journal in nutrition and dietetics, The American Journal of Clinical Nutrition (AJCN) publishes the latest research on topics in nutrition, such as obesity, vitamins and minerals, nutrition and disease, and energy metabolism.The purpose of AJCN is to publish original research studies relevant to human and clinical nutrition. Well-controlled clinical studies that describe scientific mechanisms, efficacy, and safety of dietary interventions in the context of disease prevention or a health benefit will be considered. Public health and epidemiologic studies relevant to human nutrition, and innovative investigations of nutritional questions that employ epigenetic, genomic, proteomic, and metabolomic approaches are encouraged. Solicited editorials,book reviews, solicited or unsolicited review articles, invited controversy position papers, and letters to the Editor that relate to prior AJCN articles are essential components of the AJCN. All submitted material with scientific content will undergo peer review by the Editors or their designees before acceptance for publication.