The Annals of Neurology publishes articles of broad interest in neurology, particularly those with high impact in understanding the mechanisms and treatment of diseases of the human nervous system. Although Annals publishes papers using a wide variety of clinical and basic neuroscience methods, we are most interested in those manuscripts that will be of general interest to academic neurologists, including clinical trials and other large-scale studies that inform the practice of medicine. Purely basic studies, without strong clinical or translational potential, are unlikely to have sufficient priority for publication.